ISO 22400 can be applied in aerospace and MRO environments, but it is not aerospace-specific and does not replace AS9100, regulatory, or customer KPI requirements. It provides a common structure for manufacturing KPIs (like OEE and availability), which must be carefully interpreted for HMLV, repair, and brownfield MRO contexts, and validated against existing MES/ERP data and reporting.

The aerospace manufacturing and defense industry covers the design, production, and support of aircraft, spacecraft, missiles, and related systems for commercial, civil, and military use. It operates in highly regulated, safety-critical, and export-controlled environments, with long equipment lifecycles, complex supply chains, and stringent quality, traceability, and documentation expectations.