ISO/IEC 27001 Annex A controls do apply to manufacturing equipment and OT, but they must be interpreted in an OT context. Many controls map to PLCs, CNCs, SCADA, DCS, historians, and networking, but practical implementation depends on vendor capabilities, legacy constraints, validation, and change control. Not all controls are technically or operationally feasible for every asset, so you often document justified exceptions, compensating controls, and long-term remediation plans instead of immediate full alignment.